Bone marrow histology for the diagnosis of essential thrombocythemia in children: a multicenter Italian study.
نویسندگان
چکیده
Clinic of Pediatric Hemato-Oncology, Department of Woman’s and Children’s Health, Surgical Pathology and Cytopathology Unit, Department of Medicine, and First Medical Clinic, Department of Medicine, University of Padua, Padua, Italy; Hematopathology Unit, Sant’Orsola-Malpighi Hospital, Bologna, Italy; Department of Hemato-Oncology, Gaslini Institute, Genova, Italy; Pediatric Hematology and Oncology Unit, Civico Hospital, Palermo, Italy; Pediatric Hematology, University of Torino, Turin, Italy, Pediatric Onco-Hematology Unit, University of Verona, Verona, Italy; and Pediatric
منابع مشابه
A standardized endogenous megakaryocytic erythroid colony assay for the diagnosis of essential thrombocythemia.
BACKGROUND AND OBJECTIVES The reliability of assays of endogenous megakaryocytic colony (EMC) and endogenous erythroid colony (EEC) formation for the diagnosis of thrombocytoses remains controversial. We tested the suitability of a recently developed collagen-based assay of EMC formation for the diagnosis of essential thrombocythemia (ET). DESIGN AND METHODS This was a multicenter (8 laborato...
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BACKGROUND The World Health Organization classification of myeloproliferative neoplasms discriminates between essential thrombocythemia and the prefibrotic phase of primary myelofibrosis. This discrimination is clinically relevant because essential thrombocythemia is associated with a favorable prognosis whereas patients with primary myelofibrosis have a higher risk of progression to myelofibro...
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Essential thrombocythemia (ET) is a myeloproliferative neoplasm that occurs mostly in patients above the age of 50 years. Its incidence in children is very rare, with around 100 cases reported in the literature. High-risk patients are defined by previous life threatening major thrombotic or severe hemorrhagic complication or age > 60. Those patients probably benefit from cytoreductive therapy. ...
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Controversy persists regarding the role of histopathology in the distinction between essential thrombocythemia (ET) and early-prefibrotic primary myelofi-brosis (PMF) presenting with thrombocythemia. To investigate the impact and reproducibility of bone marrow (BM) morphology according to the World Health Organization classification, 295 patients with the presumptive clinical diagnosis of eithe...
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عنوان ژورنال:
- Blood
دوره 129 22 شماره
صفحات -
تاریخ انتشار 2017